Paper Title:
Evaluation of Osteoblast Responses to Silver-Hydroxyapatite/Titania Nanoparticles In Vitro
  Abstract

In the present in vitro study, osteoblasts proliferation, vitality and ultrastructure were investigated when cultured in the presence of silver-hydroxyapatite/titania nanoparticles (nAg_HA/TiO2) compared to HA nanoparticles (nHA) at various concentrations and cell culture without nanoparticles for up to 120 hours. Results confirmed the detrimental influences of both nAg_HA/TiO2 and nHA on osteoblast growth.Cell vitality was slightly higher during the earlier 24h, but after that was inhibited. Both cell proliferation and vitality by addition of nanoparticles were restricted with concentrations of nanoparticles increasing. However, the respiration rates by addition of nanoparticles were showed higher than that of the cell culture without nanoparticles. No remarkable ultrastructure changes were showed in the osteoblasts exposed nanoparticles. The difference in cell proliferation, vitality and ultrastructure between nAg_HA/TiO2 and nHA were insignificant. It was demonstrated that biocompatibility of nAg_HA/TiO2 is almost the same as nHA.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
447-450
DOI
10.4028/www.scientific.net/KEM.330-332.447
Citation
J. C. Zhang, J. Liao, A. C. Mo, H. K. Wu, Y. B. Li, G. Y. Lv, X. Y. Li, "Evaluation of Osteoblast Responses to Silver-Hydroxyapatite/Titania Nanoparticles In Vitro", Key Engineering Materials, Vols. 330-332, pp. 447-450, 2007
Online since
February 2007
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Price
$32.00
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