Paper Title:
Preparation of Calcium Carbonate / Poly(Lactic Acid) Composite Membranes Containing Mercapto Groups
  Abstract

Mercapto group controls the adsorption and release of insulin, which is one of the proteins for enhancing the osteoblast proliferation. Silicon-ion-species were reported to stimulate the bone-forming ability of osteoblasts. The present paper describes doping with mercapto groups and silicon-ion-species in a calcium carbonate/poly (lactic acid) composite membrane, which is prepared by a sol-gel method using 3-mercaptopropyltrimethoxysilane. The membrane was amorphous and showed high flexibility. A quantitative analysis by thiol-disulfide exchange reaction using 2, 2-dipyridyl disulfide reagent showed that the amount of mercapto group existing on membrane surface was estimated to be about 5.51μmol/cm2. A trace amount of silicon-ion-species was released from the membrane after soaking in tris (hydroxymethyl) aminomethane buffer solution at 37 oC. The membrane is expected to have high bone-forming ability.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
487-490
DOI
10.4028/www.scientific.net/KEM.330-332.487
Citation
S. Tokuda, A. Obata, T. Kasuga, "Preparation of Calcium Carbonate / Poly(Lactic Acid) Composite Membranes Containing Mercapto Groups", Key Engineering Materials, Vols. 330-332, pp. 487-490, 2007
Online since
February 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Hong Song Fan, Xian Tao Wen, Yan Fei Tan, R. Wang, H.D. Cao, Xing Dong Zhang
Abstract:In recent years, electrospinning process is gradually applied in producing tissue-engineering scaffold. In this study, we chose...
2379
Authors: Toru Tonegawa, Toshiyuki Ikoma, Guo Ping Chen, M. Tanaka
Abstract:Control of protein release without the initial burst from zinc containing hydroxyapatite porous microparticles (Zn-HAp) was investigated...
857
Authors: Juris Pelss, Dagnija Loca, Liga Berzina-Cimdina, Janis Locs, Vitalijs Lakevics
Biomaterials
Abstract:In the current research slow release anticancer drug delivery system was prepared and drug release kinetics in vitro evaluated. Porous...
1770
Authors: Parichai Intaraksa, Yositar Rudeekit, Pongsaks Siriyota, P. Chaiwutthinan, M. Tajan, Thanawadee Leejarkpai
II. Biomaterials Science
Abstract:The objective of this work was to investigate the ultimate aerobic biodegradation of poly (lactic acid) (PLA) and poly (butylene...
327
Authors: Ming Bo Wang, Jian Xiong, Bin Chu, Rong Wei Tan, Wei Huang, Zhen Ding She
Chapter 2: Advanced Bio and Medical Engineering, Applications of Bioinformatics and Genetic Engineering
Abstract:A kind of PLGA microspheres was prepared with bovine serum albumin (BSA) as the model drug and poly (lactide-co-glycolide) as the matrix. The...
269