The in-vitro bioactivity of SiC growing using the innovative hybrid laser-magnetron deposition technique was investigated. The biological response has been analysed after being immersed in a human blood plasma solution for 10 days. Surface analysis by SEM microscopy shows clearly an adsorption process after immersion. The products formed are mainly attributed to a rich-calcium phosphate and silica-complexes layers. Citotoxicity test shows a normal phenotype of fibroblast cell culture on SiC and MTT assay indicates an increased viability of cells around 15% after only one day of immersion. Results obtained are supported by FTIR analysis. Strong changes in the absorbance of bands after immersion are observed, which indicates a strong bioactivity of SiC.