Paper Title:
FGF-2/Calcium Phosphate Composite Layer to Resist Bacterial Infection
  Abstract

A FGF-2-apatite composite layer (FGF-AP layer) was formed on the surface of Ti screws in a supersaturated calcium phosphate solution supplemented with FGF-2. By an in vitro study using fibroblastic NIH3T3 cells, it was confirmed that FGF-2 was immobilized in the layer without complete denaturation although the composite layer was formed at 37°C. When Ti screws with the FGF-AP layer were percutaneously implanted in the proximal tibial metaphysis of 16 rabbits, no osteomyelitis was observed in any rabbits although a FGF-2-free AP layer allowed osteomyelitis in some cases in our previous study. These results suggest that a FGF-AP layer formed on Ti screws is useful for resisting bacterial infection during external fixations.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
691-694
DOI
10.4028/www.scientific.net/KEM.330-332.691
Citation
Y. Sogo, A. Ito, H. Mutsuzaki, A. Oyane, M. Onoguchi, N. Ichinose, M. Sakane, N. Ochiai, "FGF-2/Calcium Phosphate Composite Layer to Resist Bacterial Infection", Key Engineering Materials, Vols. 330-332, pp. 691-694, 2007
Online since
February 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: E.S. Thian, Jie Huang, Serena Best, Zoe H. Barber, William Bonfield
Abstract:0.8 wt.% silicon-containing hydroxyapatite (Si-HA) thin films of thickness 600 nm have been successfully developed using a magnetron...
445
Authors: Hai Long Yang, Shouichi Somegawa, Ying Jie Yang, Zhi Chen Luo
617
Authors: Li Ping Wang, Bang Cheng Yang, Ji Yong Chen, Xing Dong Zhang
Abstract:The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro...
545
Authors: Kenkichi Sasaki, Ayako Oyane, Koji Hyodo, Atsuo Ito, Yu Sogo, Masanobu Kamitakahara, Koji Ioku
Abstract:A composite layer of fibroblast growth factor-2 (FGF-2) and low-crystalline apatite was formed on an ethylene-vinyl alcohol copolymer...
455
Authors: D. Ionita, E. Aldea, G. Stanciu, Ioana Demetrescu
Abstract:The aim of this paper was to find and establish the contact: biomaterial implant (TiAlZr) - coated with biologically active molecules; and...
733