Paper Title:
Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System
  Abstract

Control of protein release without the initial burst from zinc containing hydroxyapatite porous microparticles (Zn-HAp) was investigated with a novel formulation method. The formulation method was a coat of polyL(L-lactide; PLA) on the microparticle with nano-thickness, which obviously suppressed the initial burst of protein release compared with the microparticles without the formulation, the coat of PLA. The HAp/PLA microparticle with 1-20μm of the size distribution was available for the drug delivery carrier of proteins without the degradation.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
857-860
DOI
10.4028/www.scientific.net/KEM.330-332.857
Citation
T. Tonegawa, T. Ikoma, G. P. Chen, M. Tanaka, "Control of Protein Initial Burst from Zinc-Hydroxyapatite / Poly(L-Lactide) System", Key Engineering Materials, Vols. 330-332, pp. 857-860, 2007
Online since
February 2007
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Price
$32.00
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