Paper Title:
Study on Tissue Engineering Scaffolds of Silk Fibroin-Chitosan/ Nano-Hydroxyapatite Composite
  Abstract

The porous scaffolds of silk fibroin-chitosan /nano-hydroxyapatite (SF-CS / n-HA) were fabricated through the freeze- drying technique. Component, structure and morphology of scaffolds were studied by infrared (IR), X-ray diffusion (XRD) and scanning electron microscope (SEM), and the mechanical properties of the scaffolds were measured. The simulated body fluid (SBF) experiments were conducted to assess the bioactivity of the scaffolds. Results indicate that chemical binding is formed between HA and organics, the macropore diameter of the scaffolds varies from 150 to 400μm. The porous scaffolds with interconnected pores possess a high porosity of 78%-91% and compressive strength of 0.26 -1.96MPa, which can be controlled by adjusting the concentration of organic phases and prefreezing temperature. In the SBF tests, a layer of randomly oriented bone-like apatite crystals formed on the scaffold surface, which suggested that the composite material had good bioactivity. Studies suggest the feasibility of using SF-CS /n-HA composite scaffolds for bone tissue engineering.

  Info
Periodical
Key Engineering Materials (Volumes 330-332)
Main Theme
Edited by
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Pages
971-975
DOI
10.4028/www.scientific.net/KEM.330-332.971
Citation
G. W. Wen, J. Wang, M. Q. Li, X. C. Meng, "Study on Tissue Engineering Scaffolds of Silk Fibroin-Chitosan/ Nano-Hydroxyapatite Composite", Key Engineering Materials, Vols. 330-332, pp. 971-975, 2007
Online since
February 2007
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$32.00
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