Paper Title:
Fabrication and Characterization of Composite Microspheres Containing Carbonated Hydroxyapatite Nanoparticles
  Abstract

Nano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds.

  Info
Periodical
Key Engineering Materials (Volumes 334-335)
Edited by
J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang
Pages
1221-1224
DOI
10.4028/www.scientific.net/KEM.334-335.1221
Citation
W. Y. Zhou, M. Wang, W.L. Cheung, "Fabrication and Characterization of Composite Microspheres Containing Carbonated Hydroxyapatite Nanoparticles", Key Engineering Materials, Vols. 334-335, pp. 1221-1224, 2007
Online since
March 2007
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Price
$32.00
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