Paper Title:
Hydroxyapatite Nano-Particles Coating on the Pore Surface Within Poly(DL-lactic-co-glycolic acid) Scaffold
  Abstract

This paper describes a novel method for coating hydroxyapatite (HA, Ca10(PO4)6(OH)2) nano-particles onto poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. Paraffin micro-spheres were used as porogens to create porous scaffolds and as vehicles to transfer HA into PLGA scaffold. HA nano-particles / 50% ethanol suspension was mixed with paraffin micro-spheres. The paraffin micro-spheres / HA suspension were pressed together to form a paraffin scaffold. After it was dried, the HA was coated on the surface of the paraffin spheres. Then, PLGA solution was cast into the inter space among the paraffin micro-spheres and then the solvent was evaporated. Afterwards, the paraffin micro-spheres were dissolved and removed. PLGA scaffolds with controlled pore size, good interconnectivity and high porosity were obtained. The HA nano-particles were transferred from the paraffin surface to the surface of the pore wall throughout the PLGA scaffold.

  Info
Periodical
Key Engineering Materials (Volumes 334-335)
Edited by
J.K. Kim, D.Z. Wo, L.M. Zhou, H.T. Huang, K.T. Lau and M. Wang
Pages
1237-1240
DOI
10.4028/www.scientific.net/KEM.334-335.1237
Citation
J. S. Li, A. F.T. Mak, "Hydroxyapatite Nano-Particles Coating on the Pore Surface Within Poly(DL-lactic-co-glycolic acid) Scaffold", Key Engineering Materials, Vols. 334-335, pp. 1237-1240, 2007
Online since
March 2007
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Price
$32.00
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