Paper Title:
Inhibitory Effect of Synthetic Nano-Hydroxyapatite on Dental Caries
  Abstract

The objective of this study was to investigate the inhibitory effect of the synthetic nanohydroxyapatite (HA) on dental caries. The nano-HA was synthesized by using the depositing reaction of Ca (H2PO4)2. The artificial dental caries was made by using sour solution and inoculating Streptococcus mutans (S.mutans) to the Sprague-Dawley (SD) rat’s mouth respectively. After mineralization of solution of nano-HA for 10 days, the hardness of enamel was measured. The inhibitory effect of the synthetic nano-HA on dental caries was detected by gargling way to rinse the rat tooth with the solution of nano-HA in the animal test. Transmission electron microscopy (TEM) revealed that the dried HA particles were needle-like with ф5-20nm×60nm and the sintered HA particles were spherical with less than 100nm. The remineralized test indicated that the solution of nano-HA with different shapes enhanced the hardness of artificial caries and improved the remineralization of artificial caries. The animal test showed that the dried nano-HA had the inhibitory effect on dental caries. The good absorptive effect of the nano-HA on both the saliva protein and the glucans leads to the development of interventions that could reduce or modify bacterial colonization of tooth surfaces.

  Info
Periodical
Key Engineering Materials (Volumes 336-338)
Edited by
Wei Pan and Jianghong Gong
Pages
1538-1541
DOI
10.4028/www.scientific.net/KEM.336-338.1538
Citation
K. L. Lu, X. C. Meng, J. X. Zhang, X. Y. Li, M. L. Zhou, "Inhibitory Effect of Synthetic Nano-Hydroxyapatite on Dental Caries", Key Engineering Materials, Vols. 336-338, pp. 1538-1541, 2007
Online since
April 2007
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$32.00
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