Reconstruction of Kidney-Like Tissue Using ECM Gel and Rat Embryonic Kidney
Fragments |
| Journal |
Key Engineering Materials (Volumes 342 - 343) |
| Volume |
Advanced Biomaterials VII |
| Edited by |
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon |
| Pages |
1-4 |
| DOI |
10.4028/www.scientific.net/KEM.342-343.1 |
| Online since |
July, 2007 |
| Authors |
Ying Jian Zhu,
Wei Liu,
Wen Jie Zhang,
Guang Dong Zhou,
Guo Hua Liu,
Yi Lin Cao
|
| Keywords |
ECM Gel, Kidney-Like Tissue, PGA |
| Abstract |
Organ engineering remains a challenge to researchers. We tried to reconstruct kidney-like tissue
using tissue engineering technique. Kidney fragments were isolated from rat E16 embryonic
kidneys and seeded on either ECM gel or on polyglycolic acid (PGA) fibers, then implanted in vivo
into the subcutaneous tissue of nude mice for 2 and 3 weeks, respectively. As a negative control,
ECM alone was implanted. Results showed that kidney like tissue could be formed in ECMfragment
constructs after 2 or 3 weeks of implantation, including the formation of glomeruli,
tubules and collecting ducts. In addition, these structures seemed more mature in 3 weeks
specimens than that of 2 weeks. Further development of this model may lay a solid foundation for
kidney tissue engineering. |
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