Paper Title:
Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method
  Abstract

Poly-L-lactic acid (PLLA) is a desirable and very attractive polymer for fabricating porous scaffolds. As of now, a solvent casting method with organic solvents has been used in scaffold fabrication process. However, residual organic solvents in the scaffolds have the problems of decreasing the effect of osteogenic induction due to the hindrance of bioceramic by polymer solution and it’s harmfulness in vivo. To avoid these disadvantages of scaffolds by organic solvent casting method, we developed a new method fabricating polymer (PLLA)/ceramic (β -TCP) composite scaffolds by baking method without using solvent, and then we tested properties of scaffolds on animals. As the result, non-toxicity has been proved through animal experiment and newly fabricated polymer/ceramic composites by a novel sintering method were induced rapid bone regeneration through enhancing the interaction of cells and a bone induction factor without any host immune response.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
145-148
DOI
10.4028/www.scientific.net/KEM.342-343.145
Citation
M. S. Park, Y. M. Jung, S. H. Kim, S. H. Kim, Y. H. Kim, B. G. Min, J. W. Lee, "Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method", Key Engineering Materials, Vols. 342-343, pp. 145-148, 2007
Online since
July 2007
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Price
$32.00
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