Paper Title:
Injectable Chitosan Carrier for Demineralized Bone Matrix
  Abstract

In this study, we developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol phosphate (GP). The phase transition behaviors of chitosan and GP solution characterized as a function of temperature. The chitosan and GP solutions were shown to form a sol at room temperature, and the chitosan solution with 10-20 wt% concentrations were found to undergo sol-to-gel phase transitions as the temperature was increased. In situ gel forming implant in vivo was successfully fabricated by simple subcutaneous injection of chitosan and GP solutions with demineralized bone matrix (DBM). von Kossa images of the gel implant formed from solution with DBM revealed the presence of mineral deposits.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
177-180
DOI
10.4028/www.scientific.net/KEM.342-343.177
Citation
Y. H. Kim, M. H. Cho, I. B. Song, H. Hyun, J. W. Lee, M. S. Kim, S. J. Seo, K. W. Kang, G. S. Khang, S. Y. Yang, H. B. Lee, "Injectable Chitosan Carrier for Demineralized Bone Matrix", Key Engineering Materials, Vols. 342-343, pp. 177-180, 2007
Online since
July 2007
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Price
$32.00
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