Paper Title:
Vascular Smooth Muscle Cell Behaviors onto Epigallocatechin- 3-O-Gallate-Blended L-Lactide/ε-Caprolactone Copolymers
  Abstract

In this study, such behaviors of vascular smooth muscle cells (VSMCs), as proliferation and migration, with serum stimulation were investigated onto (−)-epigallocatechin-3-O-gallate (EGCG)-blended poly(L-lactide-co-ε-caprolactone, PLCL) copolymers (EGCG-b PLCL). VSMCs were primarily cultured from rat aorta, and EGCG-b PLCL films were fabricated by mixing PLCL with EGCG. The proliferation of VSMCs cultured onto EGCG-b PLCL film was significantly suppressed in spite of serum induction. Moreover, recovery of denuded area by VSMCs receiving conditioned media obtained from EGCG-b films was completely inhibited, whereas VSMCs onto intact films migrated into denuded area in response to serum showing essentially complete recovery. These results suggest that inhibition in the behaviors of serum-stimulated VSMCs may be mediated through the anti-proliferative effects of EGCG released from polymer films, and EGCG-b polymers can be applied for fabricating an EGCG-eluting vascular stent.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
189-192
DOI
10.4028/www.scientific.net/KEM.342-343.189
Citation
D. W. Han, H. H. Cho, D. Y. Jung, J.J. Lee, K. Matsumura, J. C. Park, S. H. Hyon, "Vascular Smooth Muscle Cell Behaviors onto Epigallocatechin- 3-O-Gallate-Blended L-Lactide/ε-Caprolactone Copolymers", Key Engineering Materials, Vols. 342-343, pp. 189-192, 2007
Online since
July 2007
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Price
$32.00
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