Paper Title:
Fabrication and Characterization of Hydrophilized Polydioxanone Scaffolds for Tissue Engineering Applications
  Abstract

Porous polydioxanone (PDO)/polyvinyl alcohol (PVA) scaffolds were fabricated by blending PDO with a small amount of PVA to improve the hydrophilicity and cell/tissue compatibility of the scaffolds for tissue engineering applications. PDO/PVA scaffolds with different PVA compositions up to 10 wt% were fabricated by a melt-molding particulate-leaching method (non-solvent method). The prepared scaffolds exhibited highly porous, uniform open-cellular pore structures. The PDO/PVA scaffolds with PVA compositions more than 5 % were easily wetted in cell culture medium. The hydrophilized PDO/PVA (5 wt%) scaffold showed better cell adhesion and growth than the control hydrophobic PDO scaffold. The PDO/PVA (5 wt%) scaffold also showed faster tissue infiltration into the scaffold than the PDO scaffold. It seems that 5 wt% addition of PVA to PDO to fabricate PDO/PVA scaffolds is enough for improving the hydrophilicity and cell/tissue compatibility of the scaffolds.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
289-292
DOI
10.4028/www.scientific.net/KEM.342-343.289
Citation
K. J. Cho, D. K. Song, S. H. Oh, Y. J. Koh, S. H. Lee, M. C. Lee, J. H. Lee, "Fabrication and Characterization of Hydrophilized Polydioxanone Scaffolds for Tissue Engineering Applications", Key Engineering Materials, Vols. 342-343, pp. 289-292, 2007
Online since
July 2007
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Price
$32.00
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