Paper Title:
Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
  Abstract

Rapamycin/curcumin co-loaded and rapamycin-loaded poly(lactide-co-glycolide)(PLGA) films were prepared by a casting method. The components of different drug-loaded films were analyzed by Fourier transform infrared spectroscopy (FTIR), and the major peaks of rapacymin and curcumin were both observed in these films. Compared to the rapamycin-loaded film, the results of in vitro platelet adhesion tests show that the number of adhered platelets reduce, and few aggregated and activated platelets are observed. The APTTs (activated partial thromboplastin time) of rapamycin/curcumin co-loaded films is nearly 6 seconds longer than for the rapamycin-loaded PLGA films. All results indicate that curcumin may suppress thrombosis activated by rapamycinloaded film, and improve the anticoagulative property. The results of alamar blue indicate that the rapamycin/curcumin co-loaded film has better antiproliferation effect than 316 stainless steel (SS).

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
317-320
DOI
10.4028/www.scientific.net/KEM.342-343.317
Citation
J. Wang, J. J. Tang, L. Ren, C. J. Pan, N. Huang, "Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation ", Key Engineering Materials, Vols. 342-343, pp. 317-320, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jia Ju Tang, Jin Wang, Chang Jiang Pan, Ya Jun Weng, Nan Huang
Abstract:Three kinds of curcumin-loaded films (3wt%, 5wt%, 8wt%) were prepared using poly(lactic acid-co-glycol acid (PLGA) as the carrier of...
481
Authors: Xin Sheng Yang, Hern Kim
Chapter 19: Nanofabrication, Nanometrology and Applications
Abstract:TiO2 nanotube was prepared by anodization method. CuO and WO3 were loaded by wet impregnation method. The...
3781
Authors: Wei Huang, Feng Wang, Hong Long Zhu
Chapter 1: Advanced Materials Research
Abstract:It is found that the fluorescence of curcumin is greatly enhanced by La3+ in the prescence of sodium dodecyl benzene sulfonate...
89