Paper Title:
Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering
  Abstract

A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco- ε-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn’t fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
321-324
DOI
10.4028/www.scientific.net/KEM.342-343.321
Citation
E. N. Chung, S. H. Kim, Y. G. Ko, J. H. Kwon, J. W. Han, I. S. Park, S. S. Han, S. H. Kim, "Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering", Key Engineering Materials, Vols. 342-343, pp. 321-324, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Gab Chul Jang, Kyong Ho Chang, Chin Hyung Lee
Abstract:During the welding process to make welded joints, residual stress is inevitably generated and weld metal is used. Welding Residual stress is...
2077
Authors: Xiu Li Wang, Jun Jie Li
Chapter 3: Security and Life Cycle Engineering Design of Civil Engineering
Abstract:The numerical simulation calculation on round steel-tubes reinforced with CFRP sheets was done through the large-scale finite element...
1595
Authors: Jiang Gui Han
Chapter 2: Nanotechnology, Mechanics,a nd Material Science
Abstract:In the paper, the interface crack of rubber - metal ring under the radial displacement load was studied by nonlinear finite element method,...
180
Authors: Cui Ping Yang, Kang Sheng Zhang, Zheng Huan Hu
Chapter 3: Modeling, Analysis and Simulation
Abstract:Cross wedge rolling hollow shafts with a mandrel has attracted much attention in the recent years because of the demand for light components....
542
Authors: Feng Li, Qi Lin Zhao, Jian Ping Wang
Chapter 2: Structural Engineering
Abstract:Compression performance of pultruded GFRP (Glass Fiber Reinforced Plastics) can be improved by confined CFRP (Carbon Fiber Reinforced...
863