Paper Title:
The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc
  Abstract

In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
389-392
DOI
10.4028/www.scientific.net/KEM.342-343.389
Citation
S. H. Kim, B. S. Choi, Y. K. Ko, H. J. Ha, S. J. Yoon, J. M. Rhee, M. S. Kim, H. B. Lee, G. S. Khang, "The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc", Key Engineering Materials, Vols. 342-343, pp. 389-392, 2007
Online since
July 2007
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Price
$32.00
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