Paper Title:
Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro
  Abstract

Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
433-436
DOI
10.4028/www.scientific.net/KEM.342-343.433
Citation
H. L. Jiang, R. B. Arote, J. S. Quan, M. K. Yoo, Y. K. Kim, I. Y. Kim, Z. S. Hong, H. G. Lee, X. Jin, Y. J. Choi, C. S. Cho, "Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro", Key Engineering Materials, Vols. 342-343, pp. 433-436, 2007
Online since
July 2007
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Price
$32.00
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