Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System |
| Journal |
Key Engineering Materials (Volumes 342 - 343) |
| Volume |
Advanced Biomaterials VII |
| Edited by |
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon |
| Pages |
445-448 |
| DOI |
10.4028/www.scientific.net/KEM.342-343.445 |
| Online since |
July, 2007 |
| Authors |
Ji Shan Quan,
Hu Lin Jiang,
Yun Jaie Choi,
Mi Kyong Yoo,
Chong Su Cho
|
| Keywords |
Bovine Serum Albumin, Chitosan Microspheres, Mucoadhesion, Oral Drug Delivery System, Thiolated Eudragit®L-100 |
| Abstract |
The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug
to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by
reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was
introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum
albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated
Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution
was shown. The in vitro release of BSA from BSA-loaded TECMs was pH-dependent.
Our results indicated that thiolated Eudragit might be a good candidate as a coating material for oral
delivery of protein drug owing to mucoadhesive and pH-sensitive properties. |
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