Paper Title:
Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System
  Abstract

The aim of this study is to prepare mucoadhesive chitosan microspheres for protein drug to deliver to intestine through oral administration. The thiolated Eudragit was synthesized by reaction between L-cysteine hydrochloride and Eudragit® L-100. About 8 mol-% of cysteine was introduced to the Eudragit-cysteine conjugate. The conjugate was used to coat bovine serum albumin (BSA)-loaded chitosan microspheres. The average particle sizes of BSA-loaded thiolated Eudragit-coated chitsoan microspheres (TECMs) were 4.06±0.74 .m and the uniform sizedistribution was shown. The in vitro release of BSA from BSA-loaded TECMs was pH-dependent. Our results indicated that thiolated Eudragit might be a good candidate as a coating material for oral delivery of protein drug owing to mucoadhesive and pH-sensitive properties.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
445-448
DOI
10.4028/www.scientific.net/KEM.342-343.445
Citation
J. S. Quan, H. L. Jiang, Y. J. Choi, M. K. Yoo, C. S. Cho, "Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System", Key Engineering Materials, Vols. 342-343, pp. 445-448, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Garnpimol C. Ritthidej, W. Pichayakorn, Chulalongkorn Kusonwiriyawong, V. Lipipun
Abstract:The purpose of this study was to prepare chitosan nanoparticles (CS NP) for controlled protein delivery. Two techniques, simple ionotropic...
751
Authors: Sung Won Kim, Yun Sik Nam, Yeon Jin Min, Jong Ho Kim, Kwang Meyong Kim, Kui Won Choi, In Sup Noh, Ik Chan Kwon
Abstract:Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated...
505
Authors: Fan Li, Feng Tian, Chang Jun Liu
Abstract:Poly(3-hydroxybutyrate) (PHB) based microspheres were prepared via double emulsion solvent evaporation using polyethylene glycol (PEG),...
54
Authors: Yong Liu, Yan Sun, Yan Li Li, Shao Chun Xu, Yao Xing Xu
Chapter 1: Frontiers of Nanoscience and Technology
Abstract:In this paper, the properties of chitosan nanoparticles and bovine serum albumin-loaded chitosan nanoparticles prepared with sodium...
160
Authors: J. Kowapradit, Theerasak Rojanarata, Tanasait Ngawhirunpat, A. Apirakaramwong, Warayuth Sajomsang, Praneet Opanasopit
III. Applications of Biomaterial
Abstract:In the present study, methylated N-(4-N,N-dimethylaminocinnamyl) chitosan (TM65CM50CS) was synthesized and investigated for oral protein drug...
465