Optimization of Experimental Conditions for Synthesis of Nanohydroxyapatite/Collagen Composites in Situ

L9 (34) orthogonal array design was employed to optimize experimental conditions for the preparation of the composite using in situ synthesis method and to analyze the relationships between experimental parameters and mechanical property of the composites. Bending strength of the composite was considered as a target property of the composites. Hydroxyapatite content in the composite, synthesis temperature and pH were chosen as main parameters. As a result of this study, bending strength of the composite appeared in peak with the increase of the hydroxyapatite content of the composites and synthesis pH, while with the increase of temperature, bending strength decreased. Optimum experimental conditions for the synthesis of the composites with higher bending strength were determined. The bending strength of the composites was 90 MPa at the optimal synthesis conditions.