Paper Title:
Preparation and Characterization of Porous Membrane for Drug Release
  Abstract

To develop osmotic granule with semi-permeable membranes, we prepared the semipermeable membranes with different pore forming agent by using solvent casting method. The membrane was consisted of cellulose acetate, Eudragit® RS, hydroxypropylcellulose (HPC), and triethylcitrate (TEC) in the presence of PEG200, PEG1, 000, or dibutylsebacate(DBS) as a pore forming agent. The produced membranes were white and elastic and exhibited soft property on touch. The release amount of pore forming agent from membrane with different pore forming agent was measured in water dissolution media and the order was PEG200 > PEG1, 000 > DBS. The formation of pore in membrane was observed by morphological SEM image after dissolution. The pore formation and porosity of membrane depended on water solubility of pore forming agent. We confirmed that pores in porous semi-permeable membrane could be controlled by the pore forming agent.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
485-488
DOI
10.4028/www.scientific.net/KEM.342-343.485
Citation
S. Y. Lee, Y. H. Cho, J. Y. Youn, M. S. Kim, B. Lee, G. S. Khang, H. B. Lee, "Preparation and Characterization of Porous Membrane for Drug Release", Key Engineering Materials, Vols. 342-343, pp. 485-488, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Rui Ping Liu, Wei Ming Su, Chang An Wang
Abstract:Porous Al2O3-SiO2-ZrO2 ceramic composite membranes were fabricated by the sol-gel method. The...
108
Authors: Hua Yuan, Bing Yu, Hai Lin Cong, Qiao Hong Peng, Yong Li Luo, Ming Chi
Chapter 3: Frontiers of Micro-Materials and Technologies, Applications
Abstract:A isoporous brominated poly (phenylene oxide) (BPPO) microfiltration membrane system, fabricated by figure breath method, was demonstrated...
237
Authors: Keila Machado Medeiros, Diego Farias Lima, Carlos Antônio Pereira de Lima, Edcleide Maria Araújo, Hélio Lucena Lira, Vanessa Nóbrega Medeiros
Chapter 8: Films and Membranes
Abstract:Membrane is a barrier that separates two phases and limits wholly or partially carrying one or several chemical species present in the...
815