Paper Title:
Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications
  Abstract

The inclusion complex of CO2-soluble peracetylated-β-cyclodextrin (PAc-β- CD), heptakis(2,3,6-tri-O-acetyl)-β-cyclodextrin, and highly water-soluble drug captopril, was prepared by a chemical solvent-free method using supercritical carbon dioxide. The captopril-PAc-β-CD inclusion complex was further confirmed by DSC and XRD studies. In- vitro release of captopril from an oily suspension confirmed that the dissolution rate of captopril was much retarded from the inclusion complex as a result of the hydrophobic properties of PAc-β-CD.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
489-492
DOI
10.4028/www.scientific.net/KEM.342-343.489
Citation
H. S. Ganapathy, M. H. Woo, Y. S. Gal, K. T. Lim, "Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications", Key Engineering Materials, Vols. 342-343, pp. 489-492, 2007
Online since
July 2007
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Price
$32.00
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