Paper Title:
Hydrophobically Modified Amphiphilic Cylodextrins as Novel Carriers for Controlled Delivery of Water-Soluble Drugs
  Abstract

Hydrophobically modified derivative of a γ-cyclodextrin, functionalized with perfluoro alkyl ester group, was prepared and investigated for its potential use as a sustained release carrier for water-soluble drug molsidomine, a peripheral nitrovasodilator used in the treatment of angina pectoris. The molecular encapsulation of molsidomine by the amphiphilic cyclodextrin, octakis(6-O-perfluorobutanoyl)-γ-cyclodextrin (γ-CyD-F), was confirmed by DSC and XRD studies. The in-vitro release of molsidomine from peanut oil suspensions into aqueous phase was found to be significantly retarded by the complexation with γ-CyD-F, mainly due to the hydrophobic properties of the γ-CyD-F.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
493-496
DOI
10.4028/www.scientific.net/KEM.342-343.493
Citation
H. S. Ganapathy, M. Y. Lee, M. H. Woo, Y. T. Jeong, K. T. Lim, "Hydrophobically Modified Amphiphilic Cylodextrins as Novel Carriers for Controlled Delivery of Water-Soluble Drugs", Key Engineering Materials, Vols. 342-343, pp. 493-496, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Cui Hua Liu, Chao Gao, De Yue Yan
Abstract:Amphiphilic hyperbranched polyamidoamine (PAMAM) and poly(sulfone-amine) (HPSA) were prepared and their dye-encapsulation properties were...
717
Authors: Feng Hong Li, Wen Jing Zhang, San Xi Li, Yong Sun, Tao Jiang
Chapter 2: Materials Engineering
Abstract:In this article, cholesterol 3-hemisuccinate (CHS) was synthesized through the functionalization of the end group of liquid crystal monomer...
197
Authors: Jun Peng Xie, Wan Wan Ding, Rui Fang Guan
Chapter 3: Chemical Materials and Technologies
Abstract:A amphiphilic triblock copolymer, poly(ethylene oxide) -poly(dimethylsiloxane) -poly(ethylene oxide) (PEO-PDMS-PEO) was synthesized via a...
117