Paper Title:
Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex
  Abstract

Stability and disintegration of natural polyelectrolyte complex microspheres for protein drugs delivery have been extensively investigated because of their great influence on the drug release patterns. In this study, we tested stability of microspheres with alginate (Alg) core layered by either chitosan (Chi) or glycol chitosan (GChi) by examining release profiles of fluorophorelabeled bovine serum albumin (BSA) and lysozyme (Lys) from the microspheres. While GChi shell was disintegrated quickly, Chi-shell microspheres showed good stability in PBS. Disintegration of the coated layer induced the core material instable. The results indicated that while the charges of the shell material provided additional diffusion barrier against the protein release, the key factor to hold the proteins inside the microspheres was the integrity of the outer coating layer.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
505-508
DOI
10.4028/www.scientific.net/KEM.342-343.505
Citation
S. W. Kim, Y. S. Nam, Y. J. Min, J. H. Kim, K. M. Kim, K. W. Choi, I. S. Noh, I. C. Kwon, "Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex ", Key Engineering Materials, Vols. 342-343, pp. 505-508, 2007
Online since
July 2007
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Price
$32.00
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