Paper Title:
All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting
  Abstract

To improve the specific accumulation in tumor sites and aqueous solubility of atRA, the core-shell type of folate-PEG-g-PEI/atRA nanoparticles were prepared by complexation between cationic PEI segments in the copolymers and anionic charged atRA, and then characterized by 1HNMR, ELS, XRD, and TEM. In vitro atRA release from the nanoparticles was investigated as a function of drug content in sink condition. Cytotocicity of atRA against HepG2, KB cell lines were also evaluated by MTT assay. The lower the drug content, the faster atRA release. atRA incorporated in folate-PEG-g-PEI/atRA nanoparticles showed much higher cytotoxic effect compared with atRA itself.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
509-512
DOI
10.4028/www.scientific.net/KEM.342-343.509
Citation
M. K. Yoo, Y. K. Kim, H. J. Jeong, H. S. Bom, C. S. Cho, "All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting ", Key Engineering Materials, Vols. 342-343, pp. 509-512, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jing Jin, Jian Peng Xue, Si Si Cui, Jie Cao, Dong Yin Zhang, Yue Qing Gu
Chapter 5: Applied Materials
Abstract:In this study, a amphiphilic copolymer, poly ((N-isopropylacrylamide)-co-acrylamide-co-...
555
Authors: Yi Xiao Wang, Zhen Qing Hou, Fei Cui, Li Hua Shen, Li Ya Xie, Qi Qing Zhang, Yun Feng Yi
Chapter 4: Micro/Nano Materials
Abstract:FA-targeted and 10-hydroxycamptothecin loaded chitosan nanoparticles (FA-HCPT-NPs) were prepared with a combination of emulsion-solvent...
434
Authors: Yang Ge, Ke Shuai Lu, Xue Yan Su
Chapter 1: Novel and Advanced Materials, Materials Science and Technologies
Abstract:These stable self-assembled nanoparticles were characterized by dynamic light scattering, transmission electron microscopy, and atomic force...
105
Authors: Alexandra M. Brown, Yoliem S. Miranda-Alarćon, Grant A. Knoll, Steven M. Romanelli, Ipsita A. Banerjee
Abstract:Although effective, chemotherapeutic drugs often cause undesired side-effects. Thus, encapsulating chemotherapeutic drugs into nanoscale drug...
33