All-Trans Retinoic Acid (atRA) Release from atRA-Loaded Folate-Poly(Ethylene Glycol)/Polyethylenimine Nanoparticles for Folate-Mediated Tumor Targeting |
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| Journal | Key Engineering Materials (Volumes 342 - 343) |
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| Volume | Advanced Biomaterials VII |
| Edited by | Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon |
| Pages | 509-512 |
| DOI | 10.4028/www.scientific.net/KEM.342-343.509 |
| Citation | Mi Kyong Yoo et al., 2007, Key Engineering Materials, 342-343, 509 |
| Online since | July, 2007 |
| Authors | Mi Kyong Yoo, You Kyoung Kim, Hwan Jeong Jeong, Hee Seung Bom, Chong Su Cho |
| Keywords | All-Trans Retinoic Acid, Drug Polymer Complex, Folate (FA), Micelle, Poly(ethylene Glycol)-g-Poly(ethyleneimine) Copolymer, Tumor Targeting |
| Abstract | To improve the specific accumulation in tumor sites and aqueous solubility of atRA, the core-shell type of folate-PEG-g-PEI/atRA nanoparticles were prepared by complexation between cationic PEI segments in the copolymers and anionic charged atRA, and then characterized by 1HNMR, ELS, XRD, and TEM. In vitro atRA release from the nanoparticles was investigated as a function of drug content in sink condition. Cytotocicity of atRA against HepG2, KB cell lines were also evaluated by MTT assay. The lower the drug content, the faster atRA release. atRA incorporated in folate-PEG-g-PEI/atRA nanoparticles showed much higher cytotoxic effect compared with atRA itself. |
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