Paper Title:
Controlled Angiogenic Factor Release from Alginate Gels
  Abstract

Therapeutic angiogenesis by localized delivery of angiogenic factors is a promising approach to treat patients with cardiovascular disease and to engineer large tissues. Vascular endothelial growth factor (VEGF) is the most common and biologically active form of the VEGF family, which acts as a mitogen to endothelial cells and is capable of specific binding to heparin. However, when VEGF is administered via bolus injection, it can be widely distributed, and its concentration is likely to be within the effective window for only a short time period due to rapid degradation. Delivery of angiogenic factors, using controlled drug delivery strategies, offers great potential to promote angiogenesis at a specific site while reducing the unwanted side effects that may occur with systemic delivery. We now report on the sustained release of VEGF from alginate gels, modified with a heparin-binding peptide. Briefly, a small peptide with the sequence of G5K(βA)FAKLAARLYRKA, which is known to specifically interact with heparin, was chemically conjugated to alginate, and the peptide-modified alginate formed gels after mixing with heparin and VEGF. The release rate of VEGF from the gels slowed in vitro for over 45 days, compared with release from non-modified alginate gels. This result suggests potential applications of alginate gels in promoting angiogenesis for therapeutic purposes, as well as for tissue engineering.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
517-520
DOI
10.4028/www.scientific.net/KEM.342-343.517
Citation
K. Y. Lee, N. Nishishita, Y. Hirano, D. Mooney, "Controlled Angiogenic Factor Release from Alginate Gels", Key Engineering Materials, Vols. 342-343, pp. 517-520, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: A.K. Go, J.K. Kim, Se Heang Oh, Soon Hong Yuk, Jin Ho Lee
Abstract:This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the...
373
Authors: Toshiyuki Ikoma, Tomohiko Yoshioka, Satoshi Nakamura, Nobutaka Hanagata, Tetsuya Abe, Masataka Sakane, Naoyuki Ochiai, M. Tanaka
Abstract:Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel...
535
Authors: Lei Li, Lu Lu, Chang Ren Zhou, Zuo Cong Xu
Abstract:Calcium alginate hydrogels, offering cells with three dimensional growing environments similar to that experienced in vivo, is an appealing...
58
Authors: Kui Lin Deng, Chun Yuan Huang, Peng Fei Zhang, Li Rong Dong, Dan Dan Li, Ting Gao, Shu Liang Wang, Wen Hui Jin
Chapter 6: New Materials and Advanced Materials
Abstract:In this paper, a new pH/temperature sensitive hydrogel bead (HME) with core-shelled structure as a drug delivery system was prepared using...
1250
Authors: S. Sriraksa, N. Sermkaew, S. Setthacheewakul, R. Wiwattanapatapee
III. Applications of Biomaterial
Abstract:Tetrahydrocurcumin (THC), one of the curcumin metabolites, exhibits pharmacological activities such as antioxidant, anti-inflammatory and...
517