Paper Title:
Self-Degradable Bioadhesive
  Abstract

To improve the conventional and commercially-available medical adhesives such as cyanoacrylate, aldehyde-based, and fibrin glue, new bioadhesive has been prepared using medical and food additives as starting materials. Aldehyde groups could be easily introduced in dextran in the presence of sodium periodate in aqueous media, and the extent of the introduction could also be controlled. In vitro degradation speed of the hydrogel prepared by mixing of aldehyded dextran with ε-poly(L-lysine) at 37oC significantly varied by acetic anhydride concentration added to ε-poly(L-lysine) from < 5h to > 5 weeks. Bonding strength of the glue was 4 times higher than that of commercial fibrin glue and almost no cytotoxicity was observed, suggesting the development of novel self-degradable bioadhesive.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
713-716
DOI
10.4028/www.scientific.net/KEM.342-343.713
Citation
N. Nakajima, H. Sugai, S. Tsutsumi, S. H. Hyon, "Self-Degradable Bioadhesive", Key Engineering Materials, Vols. 342-343, pp. 713-716, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Hyu Suk Kim, Hyug Jong Kim, Hyung Su Kim, Young Kyu Jeong, Suk Hwan Kim, Sang Woo Lee, Bong Kyo Jeong, Hyuoung Ho Lee, Byung Ho Choi
Abstract:An investigation is reported by coating BaMgAl10O17:Eu2+ phosphor by silicon oxide using catalyzed atomic layer deposition. Nanoscaled SiO2...
375
Authors: Seoung Woo Kuk, Seok Hwan Bang, In Hoe Kim, Sun Yeol Jeon, Hyeong Tag Jeon, Hyung Ho Park, Ho Jung Chang
Abstract:ZnS thin films were grown by Atomic Layer Deposition (ALD) method with Diethyl- Zinc (DEZ) and hydrogen sulfide (H2S) for the application of...
689
Authors: Jin Zhang, Shu Shen Liu, Hui Ping Deng, Shu Guang Zhu, Qi Ling
Chapter 1: Chemistry and Biotechnology in Environmental Engineering
Abstract:Various chemicals emerge in environment and exist as mixtures with different forms and concentrations. Toxicity interaction by mixtures may...
413
Authors: Somkamon Manchun, Crispin R. Dass, Pornsak Sriamornsak
Chapter 3: Biomedical and Health Applications
Abstract:To overcome major side-effects, that is, cardiotoxicity of doxorubicin (DOX), pH-responsive dextrin nanogels (DNGs) were developed for using...
227