Paper Title:
Surface Modification by Grafting with Biocompatible 2-Methacryloyloxyethyl Phosphorylcholine for Microfluidic Devices
  Abstract

Non-biofouling surfaces with polymer-based substrate were prepared for manufacturing microfluidic devices. It was done by constructing biocompatible poly(2-methacryloyloxyethyl phosphorylcholine(MPC)) brushes using surface-initiated graft polymerization method based on dithiocarbamate as photoiniferter. The density and length of the polymer chains were varied by changing the composition of the photoiniferter moiety in the base polymer (macrophotoiniferter) and the photoirradiation time, respectively. The molecular weight and thickness of the poly(MPC)- grafted chains were 320 kDa and 95±14 nm, respectively. Characterizations of the poly(MPC) modified surfaces were conducted by water contact angle, X-ray photoelectron spectroscopy, atomic force microscope. Protein adsorption resistance of these modified surfaces was then investigated by contacting with human plasma protein dissolved in phosphate buffered saline. These poly(MPC)-modified surfaces effectively reduced protein adsorption.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
789-792
DOI
10.4028/www.scientific.net/KEM.342-343.789
Citation
J. Sibarani, T. Konno, M. Takai, K. Ishihara, "Surface Modification by Grafting with Biocompatible 2-Methacryloyloxyethyl Phosphorylcholine for Microfluidic Devices", Key Engineering Materials, Vols. 342-343, pp. 789-792, 2007
Online since
July 2007
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Price
$32.00
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