Paper Title:
Blood Compatibility of Novel Zwitterionic PEG-Grafted Nitinol Alloy for Peripheral Arterial Stents
  Abstract

In this study, newly synthesized zwitterionic PEG was grafted on Nitinol alloy using oxidation treatment. The surface property and blood compatibility of surface-modified Nitinols were examined. The results of surface analysis showed that the contact angle and the ratio of oxygen to carbon significantly decreased with Nitinol alloys. The total amount of fibrinogen (0.095 μg/cm2) adsorbed onto TiNi-PEG2K-N+-S- was lower than that of TiNi control (0.12 μg/cm2). The platelet adhesion decreased in the order of TiNi control > TiNi-MPEG2K > TiNi-PEG2K-N+-S. Particularly, zwitterionic PEG with PEG2K was proven better than any others. The results indicated that zwitterionic PEG surface could significantly suppress platelet adhesion and protein adsorption as compared to other samples. The present study suggested that grafted zwitterionic PEG structure may possess improved blood compatibility.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
805-808
DOI
10.4028/www.scientific.net/KEM.342-343.805
Citation
J. H. Kim, J. S. Son, K. D. Park, J. M. Kim, J. J. Kim, K. D. Ahn, D. K. Han, "Blood Compatibility of Novel Zwitterionic PEG-Grafted Nitinol Alloy for Peripheral Arterial Stents", Key Engineering Materials, Vols. 342-343, pp. 805-808, 2007
Online since
July 2007
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Price
$32.00
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