Paper Title:
Improved Non-Invasive Biomechanical Evaluation Method for the Virtue of Risedronate
  Abstract

New medicines for treatment of osteoporotic bones have developed. In the previous studies, there were lots of pre-clinical experiments on animals to analyze the virtue of new medicine. However, the previous methods sacrificed a number of animals. They induced lots of expenses and ethical problems. In the present study, to investigate the effect of a medicine for osteoporosis by using in-vivo micro computed tomography (In-vivo Micro-CT, skyscan 1076, skyscan, Belgium) and micro finite element (*FE) analysis, morphological and mechanical characteristic changes of rat bone were detected and tracked. The 8 female Sprague-Dawley rats, used in the experiment, were randomized into 3 groups (Control, Sham and Risedronate group). The Risedronate (actonel, 0.58mg/Kg and 5days/week) for 8 weeks was administered in RIS group. The 4th lumbar vertebrae of rats were scanned by In-vivo Micro-CT with 35*m at week 0 (just before dose) and week 8 (after dose). Three-dimensional (3D) structural parameters were calculated. Simulated compression tests of 3D FE models were carried out to investigate the mechanical characteristics in the whole vertebral bone model of the 4th lumbar vertebra. The change rate of quantity and structure in Risedronate (RIS) group was smaller than that of control (CON) group. The change rate of structural modulus in RIS group was also smaller than that of CON group. This result shows the virtue of risedronate quantitatively as well as qualitatively. The study introduced the improved noninvasive biomechanical evaluation method, combined with In-vivo Micro-CT and *FE analysis, which was more effective and useful than the previous pre-clinical experiments.

  Info
Periodical
Key Engineering Materials (Volumes 342-343)
Edited by
Young-Ha Kim, Chong-Su Cho, Inn-Kyu Kang, Suk Young Kim and Oh Hyeong Kwon
Pages
921-924
DOI
10.4028/www.scientific.net/KEM.342-343.921
Citation
C. Y. Ko, T. W. Lee, D. G. Woo, H. S. Kim, B. Y. Lee, "Improved Non-Invasive Biomechanical Evaluation Method for the Virtue of Risedronate", Key Engineering Materials, Vols. 342-343, pp. 921-924, 2007
Online since
July 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Myong Hyun Baek, Ye Yeon Won, Wen Quan Cui, Byung Woo Min
Abstract:To analyze the importance of bone quality, we studied 21 primary compressive trabecular system by micro-computed tomography(micro-CT),...
917
Authors: Bin Zhang, Min Dai
Chapter 2: Biology Technology and Materials
Abstract:Osteoporosis is the most common metabolic bone disease and the most common cause of fractures in older adults. Vertebral compression fracture...
766
Authors: Mirela Toth-Tascau, Flavia Bălănean, Mircea Krepelka, Lucian Rusu, Cristian Toader-Pasti
Chapter 4: Bioengineering
Abstract:Throughout history, fractures have been treated by immobilization, traction, and internal fixation. Construction of a stabilization system...
115
Authors: Dong Mei Wu, Li Tao Zhang, Jun Zhao
Chapter 9: Methods and Algorithms of Research and Designing
Abstract:The finite element method is often used in the field of biomechanical analysis. It can study the mechanical response of the internal...
845
Authors: Girts Salms, Vladislavs Ananjevs, Vladimirs Kasyanovs, Andrejs Skagers, Ilze Salma, Janis Vetra, Vita Zalite, Liga Stipniece, Sandris Petronis
Chapter 4: Biomaterials and Applications in Biomedical Engineering
Abstract:Investigation of biomechanical properties of the rabbit bone tissue from a corner of the lower jaw was done. Experimental osteoporosis was...
224