A TiB particulate-reinforced Ti-22Al-27Nb (mol%) alloy, based on the orthorhombic intermetallic phase, was prepared using gas atomization powder metallurgy method. In the as-atomized condition, extremely fine TiB particulates of less than 1-μm diameter and 5-μm length were dispersed in the matrix. After annealing heat treatment (heat treated at 1423 K with subsequent furnace cooling), this composite exhibited a lamellar matrix microstructure and showed better creep properties than a composite produced using conventional ingot metallurgy method, with coarse TiB particulates of 5-μm diameter and 40-μm length. Coarsening of the matrix microstructure and growth of TiB particulates occurred after annealing heat treatment at higher temperature (ca. 1473 K). Creep-resistance improvement was also observed, which seemed to be mainly attribute to the effect of the matrix microstructure. From measurements of stress components and activation energy, all composites showed an identical creep mechanism: dislocation-controlled creep.