Over the last 100 years innovative techniques in the fabrication of ceramics have led to their use as high-tech materials. Inert bioceramics, such as ZrO2, have inherently low level of reactivity compared with other materials such as polymers and metals as well as surface reactive or resorbable ceramics. The aim of this study was to validate the effect of incision using a zirconia inert bioceramic scalpel to incise animal body and to prove incision property of tissues before clinic. The experiments of incisions concrescence using a sterilized Zirconia inert bioceramic scalpel were investigated in this paper. We used 4-month-old inbred line SD rats as experiment animals. They were divided into three groups to undergo incision on the back skin and subcutaneous tissue. The subcutaneous tissue and musculature samples were obtained and analyzed by optical microscopy at 3, 7 and 14 days for histopathological evaluation respectively. The experimental results showed that no wound dehiscence was observed after suture removal at 14 days after the operation. The experiments proved that an inert bioceramic scapel was nontoxic, nonallergenic, and noncarcinogenic for incisions that obtained normal concrescence criteria two weeks after operation.