Establishment of a reasonable expert system integrated developing environment (ES-IDE) is a critical factor for developing ES promptly and effectively. By current investigation and analysis of related technology, a kind of IDE for fault diagnosis expert system (FDES) on the base of Protégé+CLIPS+Eclipse tool-chain was brought forward. The model of FDES was realized by Protégé and described by ontological analysis method. Combined with CLIPS, inference engine and knowledge base (KB) were realized and applied to diagnose and deduce, the developing period of ES core framework was shortened, and flexibility of system was increased. Based on component principle, every system module was encapsulated in form of Eclipse plug-in, so users can reconstruct and reconfigure to compile and make ES application instance uniformly according to their specific demands. Industry experiments prove that this system can generate FDES in a shorter period, has strong transplanting ability and friendly human-computer interface.