The fatigue wear behavior of PA1010 composites filled with metal oxide particles was experimentally investigated. The nylon composites were prepared by compression molding method with different contents of PA1010 and CuO, Fe3O4, Al2O3 particles. The rolling contact counterpart for nylon composite samples was 1045 carbon steel ring. The rolling contact tests were performed on M-2000 wear test machine in dry friction condition. It was found that the fatigue wear measured in mass loss of nylon composites increases to rolling contact cycles. Most of the samples show an approximately linear relationship between wear mass loss and rolling cycles. Three kinds of metal oxide particles have different effects on the fatigue wear behavior of nylon composites. The contents of metal oxide particles have important influence on the fatigue wear behavior. The nylon composites filled with CuO (30 wt.%) or Fe2O3 (30 wt.%) will result in the comparatively highest wear resistance, the wear mass loss reduces to about 70% of pure nylon. Al2O3 particles is not a good choice for increasing the rolling wear resistance of nylon composites. It is found that the contact fatigue controls the wear mechanism of nylon composites under rolling contact.