Paper Title:
Comparison of HAp and β-TCP in BMP-2 Dose-Response and Release Study
| Periodical | Key Engineering Materials (Volumes 361 - 363) |
|---|---|
| Main Theme | Bioceramics 20 |
| Edited by | Guy Daculsi and Pierre Layrolle |
| Pages | 1033-1036 |
| DOI | 10.4028/www.scientific.net/KEM.361-363.1033 |
| Citation | Junichi Tazaki et al., 2007, Key Engineering Materials, 361-363, 1033 |
| Online since | November, 2007 |
| Authors | Junichi Tazaki, Toshiyuki Akazawa, Masaru Murata, Masaya Yamamoto, Yasuhiko Tabata, Jun Hino, Makoto Arisue, Takanori Shibata |
| Keywords | BMP-2, Dose-Response, HAp, Release, β-Tricalcium Phosphate (β-TCP) |
| Price | US$ 28,- |
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Abstract
The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I–labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.
