Paper Title:
Comparative Study of Ceramics Structure for Culturing Human Mesenchymal Stromal Cells
  Abstract

Hydroxyapatite (HA) ceramics together with various kinds of osteogenic cells have been used in bone tissue engineering. It is well known that the ceramics structure and composition affect cell proliferation / differentiation. In this study, three different types of HA ceramics were used to investigate initial cell attachment followed by osteoblastic differentiation of human mesenchymal stromal cells (MSCs). The results indicated that micro-pore affected the cell attachment and porosity (pore diameter and inter-pore connection) was the key to allow spacious distribution of the viable cells in the ceramics. This study also confirmed that surface pore areas of HA ceramics support the differentiation of human MSCs and thus the ceramics have the capability to regenerate damaged bone tissue.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
1067-1070
DOI
10.4028/www.scientific.net/KEM.361-363.1067
Citation
A. Matsushima, N. Kotobuki, M. Tadokoro, H. Ohgushi, "Comparative Study of Ceramics Structure for Culturing Human Mesenchymal Stromal Cells", Key Engineering Materials, Vols. 361-363, pp. 1067-1070, 2008
Online since
November 2007
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Price
$32.00
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