Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery |
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| Journal | Key Engineering Materials (Volumes 361 - 363) |
|---|---|
| Volume | Bioceramics 20 |
| Edited by | Guy Daculsi and Pierre Layrolle |
| Pages | 1219-1222 |
| DOI | 10.4028/www.scientific.net/KEM.361-363.1219 |
| Citation | Yuki Shirosaki et al., 2007, Key Engineering Materials, 361-363, 1219 |
| Online since | November, 2007 |
| Authors | Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka |
| Keywords | Biodegradability, Chitosan (CS), Chitosan Silicate Hybrid, Drug Delivery |
| Abstract | Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems. |
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