Paper Title:
Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery
  Abstract

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
1219-1222
DOI
10.4028/www.scientific.net/KEM.361-363.1219
Citation
Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, "Biodegradable Chitosan-Silicate Porous Hybrids for Drug Delivery", Key Engineering Materials, Vols. 361-363, pp. 1219-1222, 2008
Online since
November 2007
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Price
$32.00
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