In this study, we report human clinical and histological data on the use of micromacroporous biphasic calcium phosphate wedges in combination with osteosynthesis with adjustable screws for open tibial osteotomy. 42 patients were operated for open tibial osteotomy for valgisation due to incipient medial gonarthrosis. The population was composed of 43 knees (25 right knees and 18 left knees) in 13 women and 29 men, with a mean age of 46 years. Radiological follow-up at D+1, D+90 and D+360, and 12 biopsies for histology were processed after the removal of the osteosynthesis. Consolidation was obtained in 100 % of cases (except one, because of failure of the osteosynthesis). Regular bone ingrowth was observed on X-ray, with maintain of the corrections at one year in 98.5 % of cases. Only 8 % of cases showed a radiolucent interface after D+360. Histological examinations demonstrated resorption of the MBCP and large bone ingrowth. Polarised microscopy confirmed the lamellar bone, and the X-rays and microscanner revealed well mineralised and organised newly-formed bone.