The development of implantology requires enough bone support, sufficient bone architecture. The use of autograft remains the gold standard; however the surgeons use cortical bone coming from mandibular part or craniofacial site, involving severe anaesthetic bone loss. The strategy of bone substitutes in place of autograft can be an efficient method. Several patients having a sinus lift augmentation using MBCP, and BioOss have been performed in human, and bone biopsies were realized during the preparation of the site for dental implantation. Biopsies were analyzed in classical histology without decalcification and by 3D reconstruction using micro CT. Both techniques revealed bone ingrowth and MBCP resorption. For BioOss, no bone ingrtowth and resorption process were observed in spite of stability of the implant and clinical efficiency. These case reports confirm the performance of bone substitutes for Sinus Lift augmentation.