Characterization and Protein Adsorption Ability of Zinc, Iron and Magnesium Hydroxyapatite |
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| Journal | Key Engineering Materials (Volumes 361 - 363) |
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| Volume | Bioceramics 20 |
| Edited by | Guy Daculsi and Pierre Layrolle |
| Pages | 187-190 |
| DOI | 10.4028/www.scientific.net/KEM.361-363.187 |
| Citation | Toru Tonegawa et al., 2007, Key Engineering Materials, 361-363, 187 |
| Online since | November, 2007 |
| Authors | Toru Tonegawa, Toshiyuki Ikoma, Tomohiko Yoshioka, Guo Ping Chen, Nobutaka Hanagata, Junzo Tanaka |
| Keywords | Drug Delivery System, Hydroxyapatite (HA), Iron, Magnesium, Nanocrystal, Protein Adsorption, Spray-Drying Method, Zinc |
| Abstract | The adsorption properties of metal ions containing hydroxyapatite (Ca10(PO4)6(OH)2, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier. |
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