Paper Title:
A Comparison of the Efficacy of Hydoxyapatite Based Cements and Gels as Drug Delivery Matrices
  Abstract

There is a current need for the localized delivery of antibiotics in order to treat implant based infections. In this study, the efficacy of hydroxyapatite (HA) gels, HA cements, and silica gels in the delivery of vancomycin have been investigated and compared. Vancomycin release was monitored at set time points using a UV/VIS spectrophotometer (288 nm). The activity of the vancomycin released from the cements and gels was assessed using an agar diffusion test with Staphylococcus aureus. Vancomycin was released rapidly from both HA matrices, and the silica gel in the first day of the experiment, but the release rate was slowed considerably after 3 days for the HA gels. Following ten days of aging, 70% of the vancomycin remained in the HA gel matrix and the quantity released from the gel was shown to retain its effectiveness against Staphylococcus aureus.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
327-330
DOI
10.4028/www.scientific.net/KEM.361-363.327
Citation
P. J. Jiang, S. Patel, U. Gbureck, L. M. Grover, "A Comparison of the Efficacy of Hydoxyapatite Based Cements and Gels as Drug Delivery Matrices", Key Engineering Materials, Vols. 361-363, pp. 327-330, 2008
Online since
November 2007
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Price
$32.00
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