Paper Title:
Biological Evaluation of Chelate-Setting Apatite Cement Using Inositol Phosphate
  Abstract

We have successfully developed novel “chelate-setting apatite cement” using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6) . The HAp particles surface-modified with IP6 were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
335-338
DOI
10.4028/www.scientific.net/KEM.361-363.335
Citation
K. Kida, Y. Horiguchi, K. Oribe, H. Morisue, M. Matsumoto, Y. Toyama , M. Aizawa, "Biological Evaluation of Chelate-Setting Apatite Cement Using Inositol Phosphate", Key Engineering Materials, Vols. 361-363, pp. 335-338, 2008
Online since
November 2007
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Chikara Ohtsuki, Toshiki Miyazaki, Atsushi Sugino, Masao Tanihara, A. Mori, Koichi Kuramoto
361
Authors: Wei Chang Xue, Chuan Xian Ding, Cong Cao, Yuqi Dong
Abstract:A new bioceramic coating based on diopside was prepared by plasma spraying. The surface and cross-section microstructure of the coating were...
319
Authors: Si Yu Ni, Jiang Chang, Kai Li Lin, Wan Yin Zhai
Abstract:In this study, CaSiO3 (CS)/Ca3(PO4)2 (TCP) composites with 50% CS and 50% TCP sintered at different temperatures (1100oC, 1200oC and 1300oC)...
451
Authors: Li Ping Wang, Bang Cheng Yang, Ji Yong Chen, Xing Dong Zhang
Abstract:The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro...
545
Authors: Naoki Osada, Yusuke Shigemitsu, Masashi Makita, Kazuya Oribe, Mamoru Aizawa
Abstract:Hybrids of hydroxyapatite (HAp) and poly(L-lactic co glycolic) (PLGA) have been fabricated, which can be expected to be a novel filler for...
556