Paper Title:
Timed-Release Calcium Sulfate Ceramic Nanocomposites as Bone Graft Substitutes
  Abstract

Pure calcium sulfate (CS) is an excellent bone graft material because it is biocompatible, completely biodegradable, osteoconductive, safe, nontoxic and angiogenic. It also has barrier properties. However, its rapid degradation limits its use as a bone graft material. A nanocomposite of CS and poly (l lactic acid) (PLLA) in a ratio of 96:4 was developed to overcome this problem. This composite underwent slower degradation. It took 16 weeks for complete degradation whereas pure CS takes only 4 weeks. When implanted in bone defects in rabbits, it underwent complete degradation and stimulated vigorous bone formation.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
391-394
DOI
10.4028/www.scientific.net/KEM.361-363.391
Citation
S. Mamidwar, J. Ricci, H. Alexander, "Timed-Release Calcium Sulfate Ceramic Nanocomposites as Bone Graft Substitutes", Key Engineering Materials, Vols. 361-363, pp. 391-394, 2008
Online since
November 2007
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Price
$32.00
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