Apatite Formation on α-Tricalcium Phosphate/Poly(D,L-Lactide-Co-Glycolide) Nanocomposite
| Periodical | Key Engineering Materials (Volumes 361 - 363) |
|---|---|
| Main Theme | Bioceramics 20 |
| Edited by | Guy Daculsi and Pierre Layrolle |
| Pages | 459-462 |
| DOI | 10.4028/www.scientific.net/KEM.361-363.459 |
| Citation | Z. Yang et al., 2007, Key Engineering Materials, 361-363, 459 |
| Online since | November, 2007 |
| Authors | Z. Yang, E.S. Thian, Roger A. Brooks, Neil Rushton, Serena Best, Ruth Cameron |
| Keywords | Apatite, Nanocomposite, Poly(DL-Lactic-Co-Glycolic Acid), Simulated Body Fluid (SBF), α-Tricalcium Phosphate (α-TCP) |
| Price | US$ 28,- |
In this study, a biocomposite comprising nanostructured α-tricalcium phosphate (α-TCP) in a poly(D,L-lactic-co-glycolic acid) (PLGA) matrix was fabricated by a modified solution evaporation method. As a potential temporary bone fixation and substitution material, its bioactivity was evaluated by its ability to form bone-like apatite layer in simulated body fluid (SBF). Owing to the increased surface area covered by the osteoconductive bioceramic of α-TCP, rapid apatite formation was observed. After 7 days of immersion, enhanced nucleation of apatite was observed on the nanocomposite. At day 14, dense lamellar-like apatite was formed on the nanocomposite whilst apatite nucleation had only just started to develop on the surface of pure PLGA. At the same time, a preliminary in-vitro cell culture study was conducted using human osteoblast-like (HOB) cells. A significant increase in cell number with culturing time was observed for the nanocomposite. After 9 days incubation, a confluent lamellar-like apatite layer was formed on the composite surface. This apatite layer was also shown beneath the proliferating HOB cells at Day 16.
