Paper Title:
Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel
  Abstract

Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
535-538
DOI
10.4028/www.scientific.net/KEM.361-363.535
Citation
T. Ikoma, T. Yoshioka, S. Nakamura, N. Hanagata, T. Abe, M. Sakane, N. Ochiai, M. Tanaka, "Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel", Key Engineering Materials, Vols. 361-363, pp. 535-538, 2008
Online since
November 2007
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Price
$32.00
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