Paper Title:
DNA-Coatings: Bioactive Properties and Effects on Osteoblast-Like Cells
  Abstract

The aim of this study was to evaluate potential effects of DNA-coatings on calcium phosphate (CaP) nucleation from simulated body fluids (SBF) and subsequently the effects of DNA-coatings and SBF-immersed DNA coatings on the behavior of osteoblast-like cells. DNAcoatings demonstrated to enhance the nucleation and deposition of CaP from SBF compared to titanium controls. The behavior of osteoblast-like cells was affected on SBF-immersed DNAcoatings, showing an increased deposition of the extracellular matrix protein osteocalcin compared to titanium controls. These results indicate bone-bonding capacity of DNA-coatings, which needs to be confirmed using future animal experiments.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
605-608
DOI
10.4028/www.scientific.net/KEM.361-363.605
Citation
J. J.J.P. van den Beucken, X.F. Walboomers, S. C.G. Leeuwenburgh, M. F.J. Vos, N. A.J.M. Sommerdijk, R. J.M. Nolte , J. A. Jansen, "DNA-Coatings: Bioactive Properties and Effects on Osteoblast-Like Cells", Key Engineering Materials, Vols. 361-363, pp. 605-608, 2008
Online since
November 2007
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Price
$32.00
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