Paper Title:
Influence of Calcium Zirconium Phosphate Containing Coatings on Mineralization of Bone
  Abstract

Bioactive ceramics such as hydroxypatite (HA) promote and enhance biological fixation. There is still a discussion on the desired longevity of the coating. Stable coatings require an optimum between resorption rate, flexural strength and adhesive strength of the coating. Ceramic coatings containing fluorapatite (FA, Ca5(PO4)3F) and calcium zirconium phosphate (CZP, CaZr4(PO4)6) promise lower resorption rates than conventional HA coatings in the biological milieu. It is hoped that they can improve the long-term stability of implants by eliminating the detrimental resorption of coating material. For the in vivo studies plasma sprayed coatings were generated. The materials were implanted into the distal femur epiphysis of rabbits and investigated after 2, 4, 6, 12, and 24 weeks postoperatively. Histological analysis was preformed on the areas surrounding the implant. The amount of osseointegration was determined by using the automatically image analysis. The bonding strengths were compared with HA coating and uncoated titanium alloy. According to available data, there is inhibition of mineralization of bone at the interface of calcium zirconium phosphate ceramics of the described composition.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
641-644
DOI
10.4028/www.scientific.net/KEM.361-363.641
Citation
A. Bernstein, D. Nöbel, H. O. Mayr, R. Gildenhaar, G. Berger, U. Ploska, J. Brandt, "Influence of Calcium Zirconium Phosphate Containing Coatings on Mineralization of Bone", Key Engineering Materials, Vols. 361-363, pp. 641-644, 2008
Online since
November 2007
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