Paper Title:
Biomimetic Smart Hydroxyapatite/Biphasic Tricalcium Phosphate Biomatrices Induce Bone Formation
  Abstract

Long-term studies in the non-human primate Papio ursinus were set to investigate the induction of bone formation in biphasic hydroxyapatite tricalcium phosphate (HA/TCP) biomimetic matrices, 20/80 and 40/60, respectively. Biomimetic matrices were implanted in the rectus abdominis and in calvarial defects of 4 adult Papio ursinus. Morphological analyses on day 90 and 365 showed significant induction of bone formation within concavities of the biomimetic matrices implanted in both heterotopic and orthotopic sites with resorption of the implanted biomimetic matrices. The smart biomimetic matrices induced de novo bone formation even in the absence of exogenously applied osteogenic proteins of the transforming growth factor-β superfamily.

  Info
Periodical
Key Engineering Materials (Volumes 361-363)
Main Theme
Edited by
Guy Daculsi and Pierre Layrolle
Pages
981-984
DOI
10.4028/www.scientific.net/KEM.361-363.981
Citation
U. Ripamonti, P.W. Richter, R.W.N. Nilen, L.N. Ramoshebi, L. Renton, M. Heliotis, "Biomimetic Smart Hydroxyapatite/Biphasic Tricalcium Phosphate Biomatrices Induce Bone Formation", Key Engineering Materials, Vols. 361-363, pp. 981-984, 2008
Online since
November 2007
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Price
$32.00
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