This study presents the development of an ultra-precision grinding system based on a new grinding technique called the “In-Process Grinding Method (IPGM)”. IPGM which is used for grinding aspheric lens increases both the production and grinding performance, and significantly decreases total production costs. To enhance the precision grinding productivity of ultra-precision aspheric lens, we present here an ultra-precision grinding system and process for the aspheric micro-lens. The tool path was calculated and CNC program generation and tool path compensation were performed for aspheric lens. Using this ultra-precision grinding system, aspheric lens, 4mm in diameter, were successfully performed. The profile error after the first grinding without any compensation was less than 0.6μm, and surface roughness Ra was 0.01μm. In-process grinding was performed with compensation. Results of the profile accuracy P-V 0.3μm and surface roughness Ra 0.006 μm were obtained.