Yttria stabled zirconia fiber reinforced polymethyl methacrylate-polymethyl acrylate (PMMAPMA) composites (ZrO2(f)/PMMA-PMA) were prepared by a suspension polymerization method. The effects of MMA/MA volume ratio, initiator and fiber mass ratio on the mechanical properties of the composites were investigated. Results showed that the flexural strength of the composites reaches the optimum value when the volume ratio of methyl methacrylate /methyl acrylate (MMA/MA) = 9/1. With the increase of benzoyl peroxide (BPO) mass ratio, the flexural strength of ZrO2(f)/PMMA-PMA composites increases to maximum and then decreases. With the increase of ZrO2 fiber mass ratio, the microstructure of the fractured surfaces changes from smooth to crapy, implying that the toughness of the composites is improved.